W2-3 "Multi-level hierarchical modelling; with a focus on modelling of type 2 diabetes"Systems biology is a rapidly growing field, which has as its key component to integrate mathematical modelling as an analysis tool for biological data. Mathematical modelling has been used extensively in many other fields, but the application to systems biology raises some new challenges, which warrants the development of new and modified theoretical methods and modelling strategies. This workshop is devoted to one such challange: how to integrate models together in a multi-level hierarchical fashion. There will be general methodological discussions, but there will also be a clear focus on modelling of type 2 diabetes, where there will also be concrete discussions on the integration between experimental and modelling groups on various sub-systems. The talks will appear in 3 sections
- Whole-body and multi-level modelling of type 2 diabetes (Dalla Man model and its extentions to include detailed organ models and fatty acid homeostasis; brain-regulations)
- Organ specific modelling and experiments (muscle, liver, pancreas)
- Measurement technologies (omics, including mass-spec and its analysis, microdialysis)
Apart from talks, we will also have general and specific discussions, including future applications in the same direction as M-INS, the joint arrangement of a Ph.D. course, and the joint authoring of a book on multi-level modelling of type 2 diabetes.
With the hope of an interesting time in Linköping!
email with links to litterature can be found here.
Preliminary scheduleSunday June 19
14-14.15 Gunnar Cedersund, Welcome
Session on whole-body and multi-scale models
14.15-14.45 Elin Nyman, Multi-scale modelling incorporating insulin signaling in adipocytes and whole-body glucose homeostasis
14.45-15.15 Fianne Sips, A whole-body model for both glucose and fatty acid homeostasis
15.15-15.45 Coffee break
15.45-16.15 Britta Goebel, Brain centered whole-body model of the energy metabolism
16.15-16.45 Clemens Kreutz, Modelling of hepatocyte insulin signalling
16.45-end Open discussion on the intermediate steps on developing whole-body models for future hierarchical extensions
19.00 Dinner Restaurant Afrodite
Monday June 20
Session on fat, muscle, and liver
9.00-9.30 Winston Garcia-Gabin, Multi-level modelling of glucose homeostasis and type 1 diabetes
9.30-10 Peter Strålfors, Modelling as a tool to aid experiments in drawing conclusions and integrating knowledge regarding insulin signaling in primary human fat cells
10-10.30 Natal van Riel, Modelling of muscle and liver metabolism
10.30-11 Coffee break
11.00-11.30 Olof Dahlqvist Leinhard, Measuring local fat content on the whole-body scale
11.30-12.00 Discussion on strategies for developing the remaining organ modules to include in the whole-body models
12.00-14.00 Lunch, various discussions
Session on omics and other new measurement technologies
14.00 Jan Krumsiek, Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
14.30 Folke Sjöberg/Erik Tesselaar, Microdialysis to measure in vivo concentrations and fluxes in muscle, adipose, and liver
15.00-16.00 Coffee, open discussions, end of workshop
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